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How long a B12 shot lasts depends on the form of B12 used in the injection, how severe your deficiency is, and how well your body absorbs the form thats being injected

Your immune systems response affects your bodys ability to absorb vitamin B12

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These simulations indicate that within highly confined matrices, such as those encountered in vivo, the force resulting from the pressure drop across the cell dominates over the total shear force [230]